Mintex PD

Generic name: Carbinoxamine maleate and pseudoephedrine hydrochloride

Drug class: Antihistamines and decongestants

Dosage form: Oral tablet

Root of administration: Oral

Dose: Adults: 1 tablet 3 to 4 times daily as needed; do not exceed 24 mg/day. Children 12 years and older: 1 to 2 tablets 3 to 4 times daily as needed; use lowest effective dose. Children 6 to 11 years: 0.5 to 1 tablet 3 to 4 times daily as needed. Children 2 to 5 years: 0.2 to 0.4 mg/kg/day in 3 or 4 divided doses; typical dose range is 1.25 to 2.5 mL 3 to 4 times daily as needed. Use lowest effective dose. Maximum daily dose: 32 mg for adults and children 12 years and older; 16 mg for children 6 to 11 years; 8 mg for children 2 to 5 years.

Mechanism of action: Carbinoxamine is a first-generation antihistamine that blocks histamine receptors, reducing allergy symptoms. Pseudoephedrine is a sympathomimetic decongestant that constricts blood vessels in the nasal passages, decreasing nasal congestion.

Drug usage cases:

• Relief of symptoms of seasonal or perennial allergic rhinitis (e.g., rhinorrhea, sneezing)
• Allergic conjunctivitis
• Vasomotor rhinitis
• Allergic reactions to blood or plasma
• Dermatographism
• Pruritus or mild/uncomplicated allergic skin manifestations of urticaria or angioedema
• Adjunctive treatment for severe allergic reactions, including anaphylaxis, after the acute manifestations have been controlled

Drug contraindications:

• Hypersensitivity to carbinoxamine, pseudoephedrine, or any component of the formulation
• Use in pediatric patients under 2 years of age
• Concurrent use with monoamine oxidase inhibitors (MAOIs)
• Severe coronary artery disease
• Severe or uncontrolled hypertension
• Angle-closure glaucoma
• Urinary retention
• Gastrointestinal obstruction

Side effects:

• Drowsiness
• Dizziness
• Headache
• Weakness
• Insomnia
• Restlessness
• Irritability
• Photosensitivity
• Xerophthalmia
• Xerostomia
• Anorexia
• Diarrhea
• Vomiting
• Abdominal pain
• Nausea
• Dyspepsia
• Blurred vision
• Confusion
• Constipation
• Hypertension
• Sinus tachycardia
• Hypotension
• Urinary retention
• Palpitations
• Hallucinations
• Ataxia
• Excitability
• Seizures
• Visual impairment
• Psychosis

Warnings:

• Use with caution in patients with cardiovascular disease, hyperthyroidism, or hypertension
• May cause drowsiness; avoid driving or operating heavy machinery until you know how the medication affects you
• Alcohol and other central nervous system depressants may enhance drowsiness; avoid concurrent use
• Use with caution in patients with asthma or chronic obstructive pulmonary disease (COPD)
• Use with caution in patients with renal or hepatic impairment
• Use with caution in patients with gastrointestinal narrowing or obstruction
• Use with caution in patients with phenylketonuria (PKU) due to potential phenylalanine content
• Use with caution in patients with benign prostatic hyperplasia (BPH)
• Use with caution in patients with diabetes mellitus
• Use with caution in patients with glaucoma

Use during pregnancy or breastfeeding:

Carbinoxamine and pseudoephedrine are classified as Category C for pregnancy, indicating that risk cannot be ruled out. They should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Both drugs are excreted in breast milk; caution is advised when administering to nursing mothers. Consult a healthcare provider before use during pregnancy or breastfeeding.