Quelicin

Generic name: succinylcholine [ sux-i-nil-KOE-leen-KLOR-ide ]

Drug class: Neuromuscular blocking agents

Brand name: Quelicin

Dosage forms: Injectable solution.

Route of administration: Intravenous (IV) injection.

Dose: Induction of muscle relaxation: 0.6 to 1.0 mg/kg IV bolus. Maintenance: Dosage varies based on clinical need and patient response.

Mechanism of action: Succinylcholine is a depolarizing neuromuscular blocker that acts on the neuromuscular junction. It binds to nicotinic receptors on the motor end plate, causing an initial depolarization and muscle contraction. This is followed by sustained depolarization and muscle relaxation, resulting in paralysis. The drug’s effects are terminated by plasma cholinesterase, which breaks down succinylcholine.

Drug usage cases: Facilitation of endotracheal intubation. Muscle relaxation during surgical procedures or mechanical ventilation.

Drug contraindications: Known hypersensitivity to succinylcholine. History of malignant hyperthermia. Major burns or extensive trauma. Hyperkalemia or conditions predisposing to hyperkalemia (e.g., neuromuscular disorders). Genetic predisposition to prolonged neuromuscular blockade (e.g., atypical plasma cholinesterase).

Side effects: Common: Muscle fasciculations, postoperative muscle pain, transient increase in serum potassium levels. Serious: Malignant hyperthermia, severe allergic reactions, life-threatening arrhythmias, prolonged neuromuscular blockade. Rare: Rhabdomyolysis, elevated intraocular pressure, myopathy.

Warnings: Monitor for signs of malignant hyperthermia, such as rapid increase in body temperature, muscle rigidity, and metabolic acidosis. Use with caution in patients with a history of neuromuscular disorders or significant trauma. Regularly monitor potassium levels, especially in patients at risk for hyperkalemia. Ensure adequate facilities and staff for immediate management of potential severe reactions. Be aware of the potential for prolonged neuromuscular blockade in patients with atypical plasma cholinesterase.

Use during pregnancy or breastfeeding: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Succinylcholine is not typically used during labor or delivery. Consult your doctor before using this medication while breastfeeding.