Meropenem

Generic name: meropenem [ mer-oh-PEH-nem ]
Brand names: Merrem, Merrem Novaplus

Drug class: Antibiotics (Carbapenems)

Dosage form: Injection

Route of administration: Intravenous (IV)

Dose: 500 mg, 1 g, 2 g

Mechanism of action: Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to the lysis and death of the bacteria.

Drug usage cases: Meropenem is used to treat severe bacterial infections, including intra-abdominal infections, meningitis, and skin and skin structure infections.

Drug contra indications: Meropenem should not be used in patients with known hypersensitivity to meropenem, other carbapenems, or beta-lactam antibiotics.

Side effects: Common side effects include headache, nausea, diarrhea, and rash. Serious side effects may include:

• Severe allergic reactions: Risk of anaphylaxis and severe skin reactions.
• Seizures: Risk of seizures, particularly in patients with central nervous system disorders.
• Clostridioides difficile-associated diarrhea: Risk of severe diarrhea and colitis.
• Renal impairment: Potential for kidney damage.

Warnings: Meropenem can cause severe allergic reactions and should be used with caution in patients with a history of beta-lactam allergy. It can also cause seizures, particularly in patients with CNS disorders. Monitoring for signs of C. difficile-associated diarrhea is recommended during and after treatment.

Use during pregnancy or breastfeeding: Meropenem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether meropenem is excreted in human milk, so caution should be exercised when administered to breastfeeding mothers.