Quazepam

Route of administration: Oral.

Dose: Typical starting dose: 7.5 mg once daily at bedtime. Dosage range: 7.5 mg to 15 mg once daily at bedtime.

Adjustments based on patient response and tolerability.

Mechanism of action: Quazepam works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits activity in the brain. This action helps to produce a calming effect, reduce anxiety, and promote sleep. Quazepam binds to benzodiazepine receptors in the brain, which enhances GABA’s effects.

Drug usage cases: Treatment of insomnia characterized by difficulty falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.

Drug contraindications: Known hypersensitivity to quazepam or other benzodiazepines. Severe respiratory insufficiency. Severe hepatic impairment. Sleep apnea syndrome. History of substance abuse.

Side effects: Common: Drowsiness, dizziness, headache, dry mouth, weakness. Serious: Respiratory depression, severe allergic reactions, complex sleep-related behaviors (e.g., sleep-driving, sleep-eating), worsening of depression. Rare: Memory impairment, confusion, hallucinations, paradoxical reactions (e.g., agitation, aggression).

Warnings: Monitor for signs of dependence, abuse, and withdrawal symptoms. Use with caution in patients with a history of substance abuse, respiratory conditions, or hepatic impairment. Avoid abrupt discontinuation to prevent withdrawal symptoms. Be cautious of potential drug interactions, especially with other central nervous system depressants. Inform your doctor if you experience symptoms such as severe drowsiness, breathing difficulties, or unusual changes in mood or behavior.

Use during pregnancy or breastfeeding: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Benzodiazepines can cross the placenta and may affect fetal development, potentially causing congenital abnormalities or withdrawal symptoms in the newborn. Quazepam may be excreted in breast milk. Consult your doctor before using this medication while breastfeeding.