Robaxin

Generic name: methocarbamol

Drug class: Skeletal muscle relaxants

Dosage form: Tablets (500 mg, 750 mg), Injectable solution

Route of administration: Oral, Intravenous, Intramuscular

Dose:

• Oral: 500 mg to 750 mg, 3 to 4 times daily for the first 48 to 72 hours; then 500 mg to 750 mg, 3 to 4 times daily for maintenance. Maximum daily dose: 8 grams for up to 3 consecutive days; may repeat after a 48-hour drug-free interval.
• Injectable: 1 gram intravenously or intramuscularly every 8 hours; maximum daily dose: 3 grams for up to 3 consecutive days; may repeat after a 48-hour drug-free interval.

Mechanism of action: Methocarbamol is a centrally acting muscle relaxant that works by inhibiting polysynaptic reflexes in the spinal cord, leading to muscle relaxation without directly affecting muscle fibers.

Drug usage cases:

• Acute, painful musculoskeletal conditions
• Adjunct to rest and physical therapy for muscle spasms
• Tetanus (lockjaw) treatment

Drug contraindications:

• Hypersensitivity to methocarbamol
• Severe renal impairment
• Myasthenia gravis

Side effects:

• Drowsiness
• Dizziness
• Lightheadedness
• Headache
• Blurred vision
• Nausea
• Vomiting
• Stomach upset
• Flushing
• Confusion
• Memory problems
• Low blood pressure
• Skin rash
• Depressed mood
• Dry mouth
• Constipation
• Urine discoloration (blue, black, or green)

Warnings:

• May impair the ability to perform tasks requiring alertness, such as driving or operating machinery
• Alcohol may enhance drowsiness and dizziness
• Use with caution in patients with a history of seizures
• Not recommended during pregnancy and breastfeeding
• Use in geriatric patients may increase the risk of adverse effects

Use during pregnancy or breastfeeding: Methocarbamol is classified as a Category C drug during pregnancy, indicating that risk to the fetus cannot be ruled out. It is not recommended for use during breastfeeding due to potential risks to the nursing infant. Consult a healthcare provider before use in these populations.