Xtandi

Generic name: Enzalutamide

Drug class: Antiandrogens, Hormones / antineoplastics

Dosage forms: Capsules, Tablets

Root of administration: Oral

Dose: 40, 80mg

Mechanism of action: The mechanism of action of Xtandi involves targeting androgen receptors, which play a crucial role in the growth and progression of prostate cancer.

Drug usage cases: Xtandi is an androgen receptor inhibitor used to treat certain prostate cancers. Xtandi works by preventing the actions of androgens (male hormones), to help control cancer growth and decrease tumor size. Xtandi is used when prostate cancer no longer responds to hormone therapy or surgical treatment. Xtandi is also used when prostate cancer has spread to other parts of the body, and it responds to hormone therapy or surgical treatment to lower testosterone. Xtandi is also used for patients who have cancer that responds to hormone therapy or surgical treatment to lower testosterone, and their cancer has not spread to other parts of the body, but they are at high risk of cancer spreading to other parts of the body.

Drug contra indications: You should not use Xtandi if you are allergic to enzalutamide. To make sure Xtandi is safe for you, tell your doctor if you have ever had:

a seizure; a head injury, stroke, or brain tumor; heart disease, circulation problems; high blood pressure; diabetes; or high cholesterol or triglycerides (a type of fat in the blood).

Side effects: Stop taking Xtandi and get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Xtandi may cause side effects on your spinal cord. Stop taking this medicine and call your doctor at once if you have:

dizziness, spinning sensation; a seizure (black-out or convulsions); confusion, thinking problems, severe headache, vision problems; weakness, loss of consciousness; red or pink urine; heart problems – chest pain, shortness of breath (even with mild exertion); increased blood pressure – severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or signs of a lung infection – fever, cough with yellow or green mucus, stabbing chest pain, wheezing, feeling short of breath. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Warnings: Although not for use by women, Xtandi can cause birth defects if the mother or the father is taking this medicine. Use a condom and one other form of birth control to prevent pregnancy during your treatment and for at least 3 months after your treatment ends. Xtandi may cause side effects on your spinal cord. Stop taking this medicine and call your doctor at once if you have severe lower back pain, trouble walking or standing up, pain or weakness in your lower body, severe and worsening numbness or tingling, or sudden loss of bladder or bowel control.

Use during pregnancy or breastfeeding: Although not for use by women, Xtandi can cause birth defects if the mother or the father is taking this medicine. Do not use this medicine if you are pregnant. If you are taking Xtandi and your sexual partner could become pregnant, use a condom and one other form of birth control to prevent pregnancy during treatment. Keep using these birth control methods for at least 3 months after your treatment ends. Tell your doctor at once if a pregnancy occurs while either parent is being treated with enzalutamide. Although this medicine is not for use by women, it is not known whether enzalutamide passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine.