Yuvafem

Generic name: Estradiol

Drug class: Estrogens, Miscellaneous vaginal agents

Dosage form: Vaginal tablet

Route of administration: Intravaginal

Dose: 10 mcg per tablet

Mechanism of action: Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It acts locally on estrogen receptors in vaginal tissue, reversing atrophic changes by increasing vaginal epithelial cell maturation, restoring vaginal pH to premenopausal levels, improving vaginal blood flow and lubrication, and enhancing tissue elasticity and integrity. The low-dose formulation (10 mcg) is designed to provide local effects with minimal systemic absorption.

Drug usage cases:

• Treatment of moderate to severe vaginal dryness and pain with intercourse (dyspareunia) due to menopause
• Management of symptoms of vulvar and vaginal atrophy

Drug contraindications:

• Undiagnosed abnormal genital bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent neoplasia
• Active deep vein thrombosis (DVT), pulmonary embolism (PE), or history of these conditions
• Active arterial thromboembolic disease (e.g., stroke, myocardial infarction)
• Known or suspected pregnancy

Side effects:

• Upper respiratory tract infection
• Headache
• Abdominal pain
• Back pain
• Genital pruritus
• Moniliasis
• Vulvovaginal mycotic infection
• Diarrhea
• Nausea or vomiting
• Bloating
• Weight changes
• Breast tenderness
• Vaginal itching or discharge
• Changes in menstrual periods
• Breakthrough bleeding

Warnings:

• Estradiol may increase the risk of developing conditions that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
• Using estradiol can increase the risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia.
• Estradiol can slow breast milk production. Tell your doctor if you are breastfeeding.
• Estradiol should be used at the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Reevaluate postmenopausal women periodically as clinically appropriate to determine if treatment is still necessary.

Use during pregnancy or breastfeeding: Estradiol is contraindicated during pregnancy. If you become pregnant during treatment, contact your healthcare provider immediately. Estradiol can pass into breast milk and may slow breast milk production. If you are breastfeeding, consult your healthcare provider before using this medication.