Zegalogue

Generic name: dasiglucagon

Drug class: Glucose elevating agents

Dosage form: Injection (0.6 mg/0.6 mL single-dose autoinjector or prefilled syringe)

Route of administration: Subcutaneous injection

Dose: 0.6 mg administered subcutaneously; if no response after 15 minutes, an additional dose may be given

Mechanism of action: Dasiglucagon is a glucagon receptor agonist that stimulates hepatic glycogen breakdown and glucose release, increasing blood glucose levels to counteract hypoglycemia.

Drug usage cases:

• Treatment of severe hypoglycemia in adults and children aged 6 years and older with diabetes mellitus

Drug contraindications:

• Pheochromocytoma
• Insulinoma

Side effects:

• Nausea
• Vomiting
• Headache
• Diarrhea
• Injection site pain
• Hypersensitivity reactions, including anaphylactic shock with breathing difficulties and hypotension

Warnings:

• May cause substantial increase in blood pressure in patients with pheochromocytoma
• May cause hypoglycemia in patients with insulinoma
• Use with caution in patients with insufficient hepatic glycogen stores due to starvation, adrenal insufficiency, or chronic hypoglycemia
• Instruct caregivers in proper use; if no response after 15 minutes, seek emergency medical assistance

Use during pregnancy or breastfeeding: Safety and efficacy during pregnancy and breastfeeding have not been established; consult a healthcare provider before use