Acetaminophen, dextromethorphan, doxylamine, and phenylephrine
23 June, 2023
Actoplus Met XR
23 June, 2023
Acid Gone Extra Strength
Description
Generic name:
Calcium carbonate and magnesium hydroxide
Drug class:
Antacid (acid neutralizer)
Dosage form:
Chewable tablets
Root of administration:
Oral
Dose:
Adults and children 12 years and older: Chew 2–4 tablets as symptoms occur; repeat every 4 hours as needed. Do not exceed 12 tablets in 24 hours. Children under 12 years: Consult a healthcare provider.
Mechanism of action:
Calcium carbonate and magnesium hydroxide react with gastric hydrochloric acid to form neutral salts and water, increasing gastric pH and reducing acidity.
Drug usage cases:
- Relief of heartburn
- Acid indigestion
- Sour stomach
- Gastric hyperacidity
- Gastroesophageal reflux disease (GERD) symptom relief
- Occasional stomach upset with gas
Drug contra indications:
- Hypersensitivity to calcium carbonate, magnesium hydroxide, or any component
- Severe renal impairment or failure (risk of hypermagnesemia)
- Hypercalcemia or conditions leading to hypercalcemia (e.g., sarcoidosis)
- Milk-alkali syndrome
- Renal calculi with hypercalciuria
Side effects:
- Constipation (calcium component)
- Diarrhea (magnesium component)
- Flatulence and belching
- Abdominal discomfort
- Hypercalcemia (long-term or excessive use)
- Hypermagnesemia (in renal impairment or overdose)
- Metabolic alkalosis
Warnings:
- Use with caution in renal impairment, cardiovascular disease, or electrolyte imbalances
- May interfere with absorption of certain drugs (e.g., tetracyclines, fluoroquinolones, iron supplements); separate administration by at least 2 hours
- Excessive use may lead to milk-alkali syndrome
- Monitor serum electrolytes during prolonged therapy
- Not intended for chronic use without medical supervision
Use during pregnancy or breastfeeding:
Antacids containing calcium and magnesium are generally considered low risk in pregnancy and lactation. They may be used to relieve heartburn and indigestion during pregnancy. Avoid excessive use to reduce risk of electrolyte imbalance. Consult a healthcare provider for appropriate dosing and duration.
