Amlodipine and Atorvastatin Tablets

Generic name: Amlodipine and Atorvastatin

Drug class: Antihyperlipidemic combinations, Miscellaneous antihypertensive combinations

Dosage form: Oral tablet

Route of administration: Oral

Dose:

• Initial dose: 2.5 mg amlodipine and 10 mg atorvastatin once daily
• Maintenance dose: 5 mg amlodipine and 10–20 mg atorvastatin once daily
• Maximum dose: 10 mg amlodipine and 80 mg atorvastatin once daily

Mechanism of action: Amlodipine is a calcium channel blocker that relaxes blood vessels, reducing blood pressure and decreasing the heart’s workload. Atorvastatin is an HMG-CoA reductase inhibitor (statin) that decreases cholesterol production in the liver, lowering LDL cholesterol and triglyceride levels while increasing HDL cholesterol.

Drug usage cases:

• Hypertension (high blood pressure)
• Coronary artery disease
• Angina (chest pain)
• Primary hyperlipidemia
• Heterozygous familial hypercholesterolemia in adults and pediatric patients aged 10 years and older
• Homozygous familial hypercholesterolemia in adults and pediatric patients aged 10 years and older
• Primary dysbetalipoproteinemia
• Hypertriglyceridemia

Drug contraindications:

• Active liver disease or unexplained persistent elevations in liver enzymes
• Hypersensitivity to amlodipine, atorvastatin, or any excipient in the formulation
• Pregnancy
• Breastfeeding

Side effects:

• Edema (swelling), especially in the ankles and legs
• Muscle pain, tenderness, or weakness
• Abdominal pain
• Diarrhea
• Headache
• Nausea
• Fatigue
• Dizziness
• Elevated liver enzymes
• Rash

Warnings:

• Monitor liver function tests before initiating therapy and periodically thereafter
• Discontinue therapy if unexplained muscle pain, tenderness, or weakness occurs, especially if accompanied by fever or malaise
• Use caution in patients with a history of liver disease
• Monitor blood pressure regularly
• Use with caution in patients with severe aortic stenosis due to the risk of symptomatic hypotension

Use during pregnancy or breastfeeding: This medication is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, discontinue the medication and consult a healthcare provider.