Arrestin

Generic name: Aceclofenac

Drug class: Non-steroidal anti-inflammatory drug (NSAID)

Dosage form: Oral tablet

Root of administration: Oral

Dose: 100 mg to 200 mg once or twice daily, as prescribed by a healthcare professional

Mechanism of action: Aceclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased production of prostaglandins, which are mediators of pain and inflammation.

Drug usage cases:

• Management of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
• Short-term relief of acute pain, including musculoskeletal pain, back pain, toothache, and pain associated with ear and throat conditions

Drug contraindications:

• Hypersensitivity to aceclofenac or any component of the formulation
• Active or history of gastrointestinal bleeding or ulcers
• Severe heart failure
• Severe renal impairment
• Third trimester of pregnancy

Side effects:

• Gastrointestinal disturbances: nausea, vomiting, abdominal pain, dyspepsia, diarrhea, heartburn, loss of appetite
• Central nervous system effects: dizziness, drowsiness, headache
• Skin reactions: rash, pruritus
• Elevated liver enzymes
• Cardiovascular effects: increased blood pressure, edema

Warnings:

• Use with caution in patients with a history of gastrointestinal disorders, cardiovascular diseases, or renal impairment
• Monitor liver function during prolonged therapy
• Avoid concurrent use with other NSAIDs or anticoagulants
• Discontinue use if signs of gastrointestinal bleeding or ulceration occur
• May impair fertility; use caution in women attempting to conceive

Use during pregnancy or breastfeeding:

Pregnancy: Aceclofenac is contraindicated during the third trimester due to potential risks to the fetus. Use during the first and second trimesters should be avoided unless the potential benefits justify the potential risks to the fetus.

Breastfeeding: Limited data are available regarding the excretion of aceclofenac in human milk. Caution is advised when administering aceclofenac to breastfeeding women, and the decision should be made to either discontinue breastfeeding or discontinue the drug, considering the importance of the drug to the mother.