Choline magnesium trisalicylate

Generic name: Choline magnesium trisalicylate

Drug class: Nonsteroidal anti-inflammatory drug (NSAID); Salicylates

Dosage form: Oral tablet; Oral liquid

Route of administration: Oral

Dose:

• Adults: 2–3 grams daily, divided into 2–3 doses. Elderly patients may be prescribed 750 mg three times daily.
• Children: Not recommended for children under 12 kg. For children weighing 12–37 kg, the dose is 50 mg/kg/day, divided into 2 doses. For children over 37 kg, the dose is 2.25 grams daily, divided into 2 doses.

Mechanism of action: Choline magnesium trisalicylate inhibits the synthesis of prostaglandins, which are substances in the body that cause pain, fever, and inflammation. This inhibition reduces pain and inflammation associated with various conditions.

Drug usage cases:

• Relief of mild to moderate pain
• Reduction of fever
• Treatment of inflammatory conditions such as arthritis
• Management of pain, swelling, or stiffness associated with arthritis
• Relief of pain and inflammation in conditions like painful shoulder

Drug contraindications:

• Hypersensitivity to choline magnesium trisalicylate or other salicylates
• Active gastrointestinal bleeding or peptic ulcer disease
• History of gastrointestinal bleeding or ulcers
• Children and teenagers with viral infections (e.g., influenza, chickenpox) due to the risk of Reye’s syndrome
• Third trimester of pregnancy

Side effects:

• Gastrointestinal discomfort (nausea, vomiting, heartburn, abdominal pain)
• Diarrhea or constipation
• Headache, dizziness, drowsiness
• Tinnitus (ringing in the ears) or hearing loss
• Skin reactions (rash, itching, swelling)
• Elevated liver enzymes indicating potential liver dysfunction
• Kidney dysfunction, including changes in urine output
• Unusual bleeding or bruising

Warnings:

• Use with caution in patients with a history of gastrointestinal disorders, as NSAIDs can increase the risk of bleeding, ulceration, and perforation
• Monitor renal function during treatment, especially in patients with existing kidney conditions
• Use with caution in patients with liver disease; monitor liver function tests regularly
• Avoid concurrent use with other NSAIDs or salicylates to reduce the risk of adverse effects
• Discontinue use and seek medical attention if signs of an allergic reaction occur, such as difficulty breathing, swelling of the face or throat, or hives
• Alcohol consumption may increase the risk of gastrointestinal bleeding; limit alcohol intake during treatment
• Smoking can also increase the risk of gastrointestinal bleeding; consider smoking cessation
• Inform healthcare providers of NSAID use prior to surgical procedures, as it may affect bleeding risk

Use during pregnancy or breastfeeding:

Choline magnesium trisalicylate is classified as a Category C drug during pregnancy, indicating that risk to the fetus cannot be ruled out. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. NSAIDs, including choline magnesium trisalicylate, may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment when used around 20 weeks gestation or later. Therefore, it is generally recommended to avoid NSAID use during late pregnancy. Choline magnesium trisalicylate is excreted in breast milk; caution should be exercised when administering to nursing mothers, as it may cause side effects in the nursing infant. Consult a healthcare provider before using this medication during breastfeeding.