Adapalene

Generic name: adapalene [ a-DAP-a-leen ]

Drug class: Retinoid

Dosage form: Gel, Cream, Lotion

Route of administration: Topical

Available Dose:

• Gel: 0.1%, 0.3%
• Cream: 0.1%
• Lotion: 0.1%

Mechanism of action: Adapalene modulates cellular differentiation, keratinization, and inflammatory processes. It exhibits both anti-inflammatory and comedolytic effects. Adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein, thus, works as a modulator of cellular differentiation, keratinization, and inflammatory processes.

Drug usage cases: Adapalene is used primarily for the treatment of acne vulgaris. It is effective in reducing the number and severity of acne pimples and promoting quick healing of pimples that do develop.

Drug contra indications: Contraindicated in individuals with hypersensitivity to adapalene or any component of the formulation.

Side effects: Common side effects include skin irritation, redness, dryness, itching, and scaling. These are usually mild and decrease with continued use.

Warnings: Exposure to sunlight, including sunlamps, should be minimized during the use of adapalene. Patients should be advised to use sunscreen and wear protective clothing when sun exposure cannot be avoided. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes.

Use during pregnancy or breastfeeding: The use of adapalene during pregnancy should be avoided unless the benefits to the mother outweigh the risks to the fetus. It is not known whether adapalene is excreted in human milk, so caution should be exercised when adapalene is administered to a nursing woman.

Adapalene is a third-generation topical retinoid primarily used in the treatment of mild to moderate acne and is known for its tolerability compared to other retinoids. It may be used alone or in combination with other treatments for acne.