Aminocaproic acid (Oral)

Generic name: Aminocaproic acid

Drug class: Hemostatic agent

Dosage form: Oral solution, tablets

Root of administration: Oral

Dose:

• Adults: 5 grams (g) orally during the first hour, followed by 1 g per hour for up to 8 hours or until bleeding is controlled. The maximum daily dose should not exceed 24 g.
• Children: 100 mg per kilogram (kg) of body weight orally during the first hour, followed by 33.3 mg/kg per hour, not to exceed 600 mg/kg in 24 hours.

Mechanism of action: Aminocaproic acid inhibits fibrinolysis by blocking plasminogen activators and, to a lesser extent, plasmin activity, thereby stabilizing blood clots and reducing bleeding.

Drug usage cases:

• Control of bleeding in conditions with elevated fibrinolytic activity, such as after certain surgeries or trauma.
• Management of bleeding associated with hyperfibrinolysis.
• Adjunctive treatment in patients with hemophilia undergoing dental procedures.

Drug contraindications:

• Active intravascular clotting process (e.g., disseminated intravascular coagulation).
• Hypersensitivity to aminocaproic acid or any component of the formulation.
• History of thromboembolic events or known risk factors for thrombosis.

Side effects:

• Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain.
• Neurological: Dizziness, headache, fatigue, blurred vision, tinnitus.
• Musculoskeletal: Muscle cramps, myopathy, rhabdomyolysis.
• Cardiovascular: Hypotension, bradycardia, thrombosis.
• Renal: Dark-colored urine, decreased urine output, renal failure.
• Hypersensitivity reactions: Rash, pruritus, anaphylaxis.

Warnings:

• Monitor renal function during prolonged therapy due to potential nephrotoxicity.
• Use with caution in patients with a history of thromboembolic events.
• Discontinue if signs of thrombosis or embolism occur.
• Avoid concurrent use with other antifibrinolytic agents.
• Not recommended during pregnancy; use only if clearly needed and prescribed by a healthcare provider.
• Exercise caution in breastfeeding; consult a healthcare provider before use.

Use during pregnancy or breastfeeding: Aminocaproic acid is not recommended during pregnancy. If you are pregnant, thinking about becoming pregnant, or are breastfeeding, consult your doctor or pharmacist before starting this treatment.