Caplyta

Generic name: lumateperone

Drug class: Atypical antipsychotics

Dosage form: Oral capsule

Route of administration: Oral

Dose: 42 mg once daily; may be adjusted to 21 mg or 10.5 mg once daily based on individual factors

Mechanism of action: Lumateperone modulates neurotransmitter activity in the brain, including dopamine, serotonin, and glutamate, to alleviate symptoms of schizophrenia and bipolar depression.

Drug usage cases:

• Treatment of schizophrenia in adults
• Management of depressive episodes associated with bipolar I or II disorder in adults, as monotherapy or adjunctive therapy with lithium or valproate

Drug contraindications:

• Known hypersensitivity to lumateperone or any components of the formulation
• Use in elderly patients with dementia-related psychosis due to increased risk of death

Side effects:

• Sleepiness
• Dizziness
• Nausea
• Dry mouth
• Weight gain
• Movement disorders, including tardive dyskinesia
• Elevated blood glucose levels
• Elevated cholesterol and triglyceride levels
• Low white blood cell counts
• Orthostatic hypotension (low blood pressure upon standing)
• Seizures
• Impaired ability to operate machinery

Warnings:

• Increased risk of death in elderly patients with dementia-related psychosis
• Increased risk of suicidal thoughts and behaviors in children and young adults up to 24 years of age
• Potential for neuroleptic malignant syndrome, a life-threatening condition
• Risk of tardive dyskinesia, which may be irreversible
• Potential for metabolic changes, including weight gain, hyperglycemia, and dyslipidemia
• Risk of low white blood cell counts, increasing susceptibility to infections
• Potential for orthostatic hypotension, leading to falls and related injuries
• Risk of seizures
• Impaired ability to operate machinery due to drowsiness and dizziness

Use during pregnancy or breastfeeding: The safety of lumateperone during pregnancy and breastfeeding has not been established. It is recommended to consult a healthcare provider to discuss potential risks and benefits before using this medication during these periods.