Fluvoxamine

Generic name: fluvoxamine [ floo-VOX-a-meen ]
Brand names: Luvox, Luvox CR

Drug Class: Selective Serotonin Reuptake Inhibitor (SSRI)

Dosage Form: Tablets, Extended-Release Capsules

Route of Administration: Oral

Dose:

• Tablets: Typically available in 25 mg, 50 mg, 100 mg
• Extended-Release Capsules: 100 mg, 150 mg

Mechanism of Action: Fluvoxamine primarily acts by increasing serotonin levels in the central nervous system by inhibiting its reuptake at the synaptic cleft, which enhances mood and overall emotional stability.

Drug Usage Cases: Fluvoxamine is primarily used to treat obsessive-compulsive disorder (OCD) and is also used to treat social anxiety disorder, depression, panic disorder, and post-traumatic stress disorder (PTSD).

Drug Contraindications: Contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or those with a known hypersensitivity to fluvoxamine. Caution is advised in patients with a history of seizures, mania, or suicidal thoughts.

Side Effects: Common side effects include nausea, headache, insomnia, and sexual dysfunction. Serious side effects may include serotonin syndrome, suicidal thoughts, and changes in mood or behavior.

Warnings: Patients, especially those under 24 years of age, should be monitored closely for worsening depression and suicidal ideation, especially during the initial treatment phases or when doses are adjusted.

Use During Pregnancy or Breastfeeding: Fluvoxamine is classified under FDA Pregnancy Category C. There is a potential risk of persistent pulmonary hypertension of the newborn (PPHN) when used during pregnancy. Decisions to use during pregnancy should consider the potential benefits and risks. Fluvoxamine is excreted in breast milk; therefore, caution should be exercised when fluvoxamine is administered to a nursing mother.