Halfprin

Generic name: aspirin

Drug class: Platelet aggregation inhibitors, Salicylates

Dosage form: 162 mg enteric-coated tablet

Route of administration: Oral

Dose: 162 mg once daily, typically taken with food to minimize gastrointestinal irritation

Mechanism of action: Aspirin irreversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased production of prostaglandins and thromboxane A2, thereby reducing inflammation, pain, and platelet aggregation.

Drug usage cases:

• Acute myocardial infarction (heart attack)
• Angina pectoris prophylaxis
• Ischemic stroke prophylaxis
• Osteoarthritis
• Rheumatoid arthritis
• Fever reduction
• Pain relief

Drug contraindications:

• Hypersensitivity to aspirin or other NSAIDs
• Active gastrointestinal bleeding or peptic ulcer disease
• Severe renal impairment
• Active bleeding disorders (e.g., hemophilia)
• Children and adolescents with viral infections (due to risk of Reye’s syndrome)

Side effects:

• Gastrointestinal irritation (e.g., nausea, vomiting, dyspepsia)
• Gastrointestinal bleeding
• Allergic reactions (e.g., rash, urticaria, anaphylaxis)
• Renal dysfunction
• Elevated liver enzymes
• Prolonged bleeding time
• Headache
• Dizziness
• Tinnitus (ringing in the ears)

Warnings:

• Use with caution in patients with a history of gastrointestinal ulcers or bleeding
• Monitor renal function in patients with pre-existing kidney disease
• Discontinue use prior to surgical procedures to reduce bleeding risk
• Avoid concurrent use with other NSAIDs to minimize gastrointestinal and renal risks
• Not recommended for use in children and adolescents with viral infections due to risk of Reye’s syndrome

Use during pregnancy or breastfeeding:

Aspirin is classified as a Category D drug during pregnancy, indicating that there is evidence of risk to the fetus. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Aspirin is excreted in breast milk; therefore, caution should be exercised when administering to nursing mothers. It is advisable to consult a healthcare provider before using aspirin during pregnancy or breastfeeding.