Jadelle

Generic name: levonorgestrel [ lee-voe-nor-JES-trel ]

Drug class: Contraceptives (Progestin implants)

Dosage form: Subdermal implant

Route of administration: Subdermal (under the skin)

Dose: Each Jadelle implant contains 75 mg of levonorgestrel, typically inserted as two rods.

Mechanism of action: Jadelle releases levonorgestrel, a synthetic progestin, which prevents pregnancy primarily by inhibiting ovulation, thickening cervical mucus to prevent sperm penetration, and altering the endometrium to prevent implantation.

Drug usage cases: Jadelle is used for long-term contraception, providing protection against pregnancy for up to five years.

Drug contra indications: Jadelle should not be used in individuals with known hypersensitivity to levonorgestrel or any component of the implant, active thromboembolic disorders, undiagnosed vaginal bleeding, severe liver disease, or breast cancer.

Side effects: Common side effects include irregular menstrual bleeding, headache, and breast tenderness. Serious side effects may include:

• Thromboembolic events: Increased risk of blood clots.
• Liver dysfunction: Potential for liver enzyme elevation and liver damage.
• Ectopic pregnancy: Increased risk if pregnancy occurs.
• Hypertension: Potential for elevated blood pressure.

Warnings: Jadelle can increase the risk of thromboembolic events, particularly in women with other risk factors. Liver function tests should be monitored in patients with a history of liver disease. Regular monitoring of blood pressure is recommended.

Use during pregnancy or breastfeeding: Jadelle is not indicated for use during pregnancy. If pregnancy occurs with the implant in place, it should be removed due to the risk of ectopic pregnancy. Levonorgestrel is excreted in breast milk, but it is generally considered safe for use during breastfeeding.