Jadenu

Generic name: Deferasirox

Drug class: Chelating agents

Dosage form: Tablet, Suspension tablets

Root of administration: Oral

Dose: Tablet: 90, 180, 360 mg, Suspension tablets:125, 250, 500 mg

Mechanism of action:  Jadenu binds to iron and removes it from the bloodstream.

Drug usage cases: Jadenu is usded in people 2 years of age and older who have an increased amount of iron in their blood for a long period of time (chronic), caused by repeated blood transfusions. Jadenu is also used in certain people 10 years of age or older with thalassemia who have an increased amount of iron in their blood but who are not receiving regular blood transfusions.

Drug contra indications: You should not use Jadenu if you are allergic to deferasirox, or if you have:

severe liver or kidney disease, advanced cancer, a bone marrow disorder; or low levels of platelets in your blood. To make sure Jadenu is safe for you, tell your doctor if you have ever had:

kidney disease, liver disease, anemia (low red blood cells), cancer (especially blood cell cancer such as leukemia), a stomach ulcer, stomach or intestinal bleeding, vision or hearing problems; or a weak immune system caused by disease (such as cancer, HIV, or AIDS), or by receiving steroids, chemotherapy, or radiation.

Side effects: Get emergency medical help if you have signs of an allergic reaction to Jadenu (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Stop using Jadenu and call your doctor at once if you have:

problems with vision or hearing, kidney problems – little or no urination, swelling in your feet or ankles, feeling tired or short of breath, liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), low blood cell counts – fever, chills, mouth sores, skin sores, pale skin, easy bruising, unusual bleeding, cold hands and feet, feeling light-headed or short of breath; or signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Serious side effects may be more likely in older adults.

Warnings: You should not use Jadenu if you have severe kidney or liver disease, advanced cancer, a blood cell or bone marrow disorder, or low levels of platelets in your blood. Deferasirox can harm your liver or kidneys. Call your doctor at once if you have swelling, shortness of breath, pain in your upper stomach, loss of appetite, little or no urinating, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Jadenu may also cause stomach or intestinal bleeding. Call your doctor at once if you have symptoms of stomach bleeding such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Use during pregnancy or breastfeeding: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Jadenu can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. You should not breast-feed while you are taking Jadenu.