Jatamansi

Scientific Name: Nardostachys jatamansi DC.

Drug class: Herbal medicine (Traditional Ayurvedic herb)

Dosage form: Capsule, Powder, Essential oil

Route of administration: Oral, Topical

Dose: Typically, 250 mg to 500 mg of the extract taken once or twice daily for capsules; dosage for powder and oil varies based on formulation and intended use.

Mechanism of action: Jatamansi is believed to exert its effects through modulation of neurotransmitter levels, antioxidant activity, and neuroprotective properties. It is traditionally used for its calming and sedative effects, likely due to its influence on the GABAergic system and its ability to reduce oxidative stress.

Drug usage cases: Jatamansi is used in traditional medicine to treat anxiety, insomnia, epilepsy, and cognitive disorders. It is also used for its potential neuroprotective, anti-inflammatory, and antioxidant properties.

Drug contra indications: Jatamansi should not be used in individuals with known hypersensitivity to Nardostachys jatamansi or its components. Caution is advised in patients with pre-existing liver conditions or those taking medications that affect liver function.

Side effects: Common side effects are generally mild and may include digestive upset, dizziness, and drowsiness. Serious side effects are rare but may include:

• Hepatotoxicity: Potential for liver enzyme elevation and liver damage.
• Allergic reactions: Risk of hypersensitivity reactions.
• Sedation: Excessive drowsiness or sedation, especially when taken in large doses.

Warnings: Jatamansi can cause sedation and should be used with caution in individuals who operate heavy machinery or drive. Liver function should be monitored in patients with a history of liver disease. Due to its sedative effects, it should be used with caution in combination with other CNS depressants.

Use during pregnancy or breastfeeding: The safety of Jatamansi during pregnancy and breastfeeding is not well established. It should be used with caution and under the supervision of a healthcare provider if needed during pregnancy or breastfeeding.