Jemperli

Generic name: dostarlimab-gxly

Drug class: PD-1 inhibitors (Programmed death receptor-1 inhibitors)

Dosage form: Injection

Route of administration: Intravenous (IV)

Dose: Typically, 500 mg every three weeks for the first four doses, followed by 1000 mg every six weeks thereafter.

Mechanism of action: Jemperli is a monoclonal antibody that blocks PD-1 receptors on T-cells, preventing the interaction with PD-L1 and PD-L2 ligands. This inhibition enhances T-cell activity against cancer cells, promoting an immune-mediated attack on tumors.

Drug usage cases: Jemperli is used to treat adult patients with mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) endometrial cancer that has progressed on or after prior treatment and who have no satisfactory alternative treatment options.

Drug contra indications: Jemperli should not be used in patients with known hypersensitivity to dostarlimab or any component of the formulation.

Side effects: Common side effects include fatigue, nausea, diarrhea, and anemia. Serious side effects may include:

• Immune-mediated adverse reactions: Including pneumonitis, colitis, hepatitis, and endocrinopathies.
• Infusion-related reactions: Risk of hypersensitivity during or after infusion.
• Hepatotoxicity: Potential for liver enzyme elevation and liver damage.
• Nephrotoxicity: Risk of kidney damage.

Warnings: Jemperli can cause severe and potentially fatal immune-mediated adverse reactions affecting various organ systems. Patients should be monitored for signs and symptoms of these conditions, and treatment should be withheld or discontinued based on severity. Liver and kidney function should be monitored periodically during treatment.

Use during pregnancy or breastfeeding: Jemperli can cause fetal harm when administered to pregnant women. It should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus. It is unknown whether dostarlimab is excreted in human milk, so caution should be exercised when administered to breastfeeding mothers.