Nicotine Transdermal System Step 1

Generic name: Nicotine

Drug class: Smoking cessation agents

Dosage form: Transdermal patch

Root of administration: Transdermal

Dose: 21 mg delivered over 24 hours

Mechanism of action: Nicotine is a stimulant that binds to nicotinic acetylcholine receptors in the brain, leading to the release of neurotransmitters such as dopamine, which helps reduce withdrawal symptoms and nicotine cravings associated with quitting smoking.

Drug usage cases:

• Smoking cessation aid

Drug contraindications:

• Hypersensitivity to nicotine or any component of the patch
• Non-smokers

Side effects:

• Skin reactions at the application site (e.g., redness, itching, swelling)
• Insomnia or sleep disturbances
• Headache
• Dizziness
• Gastrointestinal discomfort (e.g., nausea, vomiting)
• Increased heart rate
• Elevated blood pressure

Warnings:

• Use with caution in individuals with cardiovascular conditions, such as heart disease, recent heart attack, or irregular heartbeat, as nicotine can increase heart rate and blood pressure.
• Not recommended for use in pregnant or breastfeeding women unless advised by a healthcare provider, as nicotine can harm the developing fetus or nursing infant.
• Keep out of reach of children and pets; used patches contain enough nicotine to be harmful if ingested.
• Dispose of used patches by folding sticky ends together and placing them back in the pouch to prevent accidental exposure.

Use during pregnancy or breastfeeding: Nicotine use during pregnancy or breastfeeding is not recommended due to potential risks to the developing fetus or nursing infant. If considering nicotine replacement therapy during these periods, consult a healthcare provider to weigh the potential benefits and risks.