Omeprazole

Pronunciation: oh-MEP-ra-zol
Generic name: omeprazole
Brand names: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, PriLOSEC, PriLOSEC OTC, Zegerid (Original Formulation)
Dosage forms: oral delayed release capsule (10 mg; 20 mg; 40 mg), oral delayed release tablet (20 mg), oral powder for reconstitution, delayed release (10 mg; 2.5 mg), oral suspension (2 mg/mL)
Drug class: Proton pump inhibitors

Available Dose:

• Tablets and Capsules: 20 mg, 40 mg

Mechanism of action: Omeprazole inhibits the hydrogen-potassium ATPase enzyme (the proton pump) in the parietal cells of the stomach, reducing gastric acid secretion.

Drug usage cases: Omeprazole is used for the treatment of acid-related conditions such as gastric ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Drug contraindications: Contraindicated in patients with known hypersensitivity to omeprazole or any of its components.

Side effects: Common side effects include headache, abdominal pain, nausea, diarrhea, and constipation. Rarely, it may cause allergic reactions.

Warnings: Caution is advised in patients with hepatic impairment. Omeprazole should be used with caution in patients with a history of liver disease.

Use during pregnancy or breastfeeding: Omeprazole is categorized as a pregnancy category C drug. It should only be used during pregnancy if needed. Omeprazole is excreted in human milk; therefore, caution should be exercised when administered to breastfeeding women.