Orphenadrine, aspirin, and caffeine

Generic name: Orphenadrine Citrate, Aspirin, and Caffeine

Drug class: Skeletal muscle relaxant combinations

Dosage form: Oral tablet

Root of administration: Oral

Dose: Adults: 1 to 2 tablets 3 to 4 times daily

Mechanism of action: Orphenadrine acts centrally to produce muscle relaxant effects; aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that relieves pain and reduces fever; caffeine is a central nervous system stimulant that enhances the effects of pain relievers.

Drug usage cases:

• Symptomatic relief of mild to moderate pain from acute musculoskeletal disorders
• Adjunct to rest and physical therapy for discomfort associated with acute painful musculoskeletal conditions

Drug contraindications:

• Hypersensitivity to any component of the combination
• Glaucoma
• Pyloric or duodenal obstruction
• Achalasia
• Prostatic hypertrophy
• Obstructions at the bladder neck
• Myasthenia gravis
• Children under 12 years of age
• Patients with chickenpox or influenza symptoms

Side effects:

• Gastrointestinal bleeding
• Light-headedness
• Dizziness
• Syncope
• Exfoliative dermatitis
• Stevens-Johnson Syndrome
• Toxic epidermal necrolysis
• Fixed drug eruption

Warnings:

• May impair the ability to perform potentially hazardous activities such as operating machinery or driving
• Use with caution in patients with peptic ulcers and coagulation abnormalities
• Reye’s Syndrome risk in individuals with chickenpox, influenza, or flu symptoms
• Use during pregnancy may harm the unborn baby if taken at 20 weeks or later; consult a doctor if between 20 to 30 weeks pregnant; not recommended after 30 weeks
• Use during breastfeeding: weigh potential benefits against potential risks; no adequate studies in women

Use during pregnancy or breastfeeding:

Orphenadrine Citrate, Aspirin, and Caffeine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Aspirin may harm an unborn baby if taken at 20 weeks or later in pregnancy. If you are between 20 to 30 weeks pregnant, consult your doctor before taking this medication. It is not recommended after 30 weeks of pregnancy. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.