Palgic

Generic name: Carbinoxamine

Drug class: Antihistamines

Dosage form: 4 mg tablets, 4 mg/5 mL oral solution

Root of administration: Oral

Dose: Adults: 4 to 8 mg orally every 6 to 8 hours; not to exceed 24 mg/day. Children over 2 years: 2 mg orally every 6 to 8 hours; not to exceed 12 mg/day. Children under 2 years: Not recommended due to risk of serious adverse effects.

Mechanism of action: Carbinoxamine is a first-generation antihistamine that blocks histamine H1 receptors, reducing allergic symptoms by preventing histamine from binding to its receptors in the body.

Drug usage cases:

• Seasonal allergic rhinitis (hay fever)
• Perennial allergic rhinitis
• Vasomotor rhinitis
• Allergic conjunctivitis
• Urticaria (hives)
• Angioedema
• Dermatographism
• Adjunctive treatment for anaphylactic reactions (in combination with epinephrine)
• Amelioration of the severity of allergic reactions to blood or plasma

Drug contra indications:

• Hypersensitivity to carbinoxamine or any component of the formulation
• Concurrent use with monoamine oxidase inhibitors (MAOIs)
• Newborns and premature infants
• Breastfeeding women
• Lower respiratory tract symptoms, such as asthma

Side effects:

• Common: Sedation, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation, headache
• Serious: Confusion, urinary retention, glaucoma exacerbation, arrhythmias

Warnings:

• Use with caution in elderly patients due to increased risk of side effects
• May impair mental alertness; avoid driving or operating heavy machinery until effects are known
• Alcohol and other central nervous system depressants may enhance sedative effects
• Use with caution in patients with cardiovascular disease, hypertension, hyperthyroidism, or prostatic hypertrophy
• Not recommended for children under 2 years of age due to risk of serious adverse effects

Use during pregnancy or breastfeeding: Carbinoxamine is classified as a pregnancy category C drug, indicating that risk to the fetus cannot be ruled out. It is excreted in breast milk; therefore, breastfeeding is contraindicated during treatment. Consult a healthcare provider before use during pregnancy or lactation.