Qbrexza

Generic name: glycopyrronium tosylate [ glye-koe-pir-OH-nee-um-TOS-i-late ]

Drug class: Miscellaneous topical agents

Brand name: Qbrexza

Dosage forms: Topical cloth.

Route of administration: Topical (applied to the skin).

Dose: Apply one cloth to the affected area (underarms) once daily.

Mechanism of action: Glycopyrronium tosylate is an anticholinergic agent that works by blocking acetylcholine at muscarinic receptors in the sweat glands. This inhibition reduces the production of sweat in the treated area. By preventing acetylcholine from binding to its receptors, Qbrexza decreases the amount of sweat released, helping to manage excessive sweating (hyperhidrosis).

Drug usage cases: Treatment of primary axillary hyperhidrosis (excessive sweating) in adults and children aged 9 years and older.

Drug contraindications: Known hypersensitivity to glycopyrronium or any component of the formulation. Glaucoma, especially narrow-angle glaucoma. Urinary retention. Severe gastrointestinal conditions (e.g., obstructive disease).

Side effects: Common: Dry mouth, irritation at the application site, headache, dry skin. Serious: Severe allergic reactions, blurred vision, urinary retention, gastrointestinal symptoms (e.g., constipation). Rare: Glaucoma exacerbation, systemic anticholinergic effects (e.g., confusion, hallucinations).

Warnings: Monitor for signs of systemic anticholinergic effects, especially if applied to large areas or used excessively. Avoid contact with eyes and mucous membranes to prevent irritation. Inform your doctor if you experience symptoms of an allergic reaction, such as rash, itching, or swelling. Use with caution in patients with a history of glaucoma, urinary issues, or gastrointestinal problems. Regularly evaluate the effectiveness and tolerability of the treatment.

Use during pregnancy or breastfeeding: There is limited information on the use of glycopyrronium tosylate during pregnancy. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if glycopyrronium is excreted in breast milk. Consult your doctor before using this medication while breastfeeding.