Vascepa

Generic name: icosapent ethyl

Drug class: Omega-3 fatty acid ethyl ester

Dosage form: Capsule, liquid-filled

Root of administration: Oral

Dose: 4 grams per day, taken in two divided doses with food; either four 0.5-gram capsules twice daily or two 1-gram capsules twice daily

Mechanism of action: Icosapent ethyl is a purified form of eicosapentaenoic acid (EPA), an omega-3 fatty acid. It reduces triglyceride levels and has anti-inflammatory effects, which may contribute to cardiovascular risk reduction.

Drug usage cases:

• Adjunct to maximally tolerated statin therapy to reduce the risk of heart attack, stroke, coronary revascularization, and unstable angina requiring hospitalization in adults with elevated triglyceride levels (≥150 mg/dL) and established cardiovascular disease or diabetes mellitus with two or more additional risk factors for cardiovascular disease
• Adjunct to diet to reduce triglyceride levels in adult patients with severe hypertriglyceridemia (≥500 mg/dL)

Drug contraindications:

• Hypersensitivity to icosapent ethyl or any component of the formulation

Side effects:

• Serious bleeding events, especially in patients on anticoagulant or antiplatelet therapy
• Heart rhythm abnormalities, including atrial fibrillation and atrial flutter
• Allergic reactions, particularly in individuals allergic to fish or shellfish
• Musculoskeletal pain
• Peripheral edema (swelling of the hands, legs, or feet)
• Constipation
• Gout

Warnings:

• Monitor for bleeding risk, especially in patients on anticoagulant or antiplatelet therapy
• Assess for heart rhythm abnormalities, particularly in patients with a history of arrhythmias
• Discontinue use if signs of allergic reactions occur
• Monitor liver function during treatment

Use during pregnancy or breastfeeding: Safety and efficacy during pregnancy and lactation have not been established. Use only if the potential benefit justifies the potential risk to the fetus or nursing infant. Consult a healthcare provider before use.