Wera

Generic name: Norethindrone and Ethinyl Estradiol

Drug class: Combination oral contraceptive (progestin and estrogen)

Dosage form: Oral tablet

Route of administration: Oral

Dose: 0.5 mg norethindrone and 35 mcg ethinyl estradiol per tablet

Mechanism of action: Wera is a combination oral contraceptive containing norethindrone (a progestin) and ethinyl estradiol (an estrogen). It primarily prevents pregnancy by inhibiting ovulation, thickening cervical mucus to impede sperm penetration, and altering the endometrial lining to prevent implantation of a fertilized egg.

Drug usage cases:

• Contraception
• Regulation of menstrual cycles
• Management of dysmenorrhea (painful periods)
• Reduction of menstrual blood loss
• Management of acne vulgaris

Drug contraindications:

• Known or suspected pregnancy
• History of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism)
• History of stroke or myocardial infarction
• Uncontrolled hypertension
• Active or history of liver disease (e.g., cirrhosis, liver tumors)
• Known or suspected breast cancer or other estrogen-dependent neoplasms
• Undiagnosed abnormal vaginal bleeding
• Hypersensitivity to any component of the product

Side effects:

• Headaches
• Nausea
• Breast tenderness
• Elevated blood pressure
• Elevated blood sugar levels
• Swelling of the feet or ankles
• Changes in menstrual flow (e.g., breakthrough bleeding, amenorrhea)
• Mood changes
• Weight changes
• Decreased libido

Warnings:

• Smoking increases the risk of serious cardiovascular events, especially in women over 35 years old.
• Does not protect against sexually transmitted infections (STIs); use barrier methods for STI prevention.
• Regular medical check-ups are recommended to monitor blood pressure, breast health, and other relevant parameters.
• May affect lipid and carbohydrate metabolism; monitor lipid profiles and glucose tolerance in at-risk individuals.
• Discontinue use if pregnancy is suspected or confirmed.
• Use with caution in women with a history of depression or mood disorders.
• May interact with other medications; inform healthcare providers of all concurrent medications.

Use during pregnancy or breastfeeding:

Wera is contraindicated during pregnancy. If pregnancy occurs during use, discontinue immediately. Small amounts of hormones may be excreted in breast milk, potentially affecting the nursing infant. It is advisable to consult a healthcare provider before using Wera during breastfeeding to assess potential risks and benefits.