Xpovio

Generic name: Selinexor

Drug class: Miscellaneous antineoplastics

Dosage forms: Tablet

Root of administration: Oral

Dose: 40, 60, 80, 100, 120 mg

Mechanism of action: Xpovio works by binding to XPO1 and preventing its interaction with the nuclear export signals on the target proteins. This inhibition of XPO1 leads to the nuclear retention of tumor-suppressor proteins and other regulatory proteins, allowing them to carry out their normal functions within the nucleus. By restoring the proper localization and activity of these proteins, Xpovio helps to inhibit cancer cell growth and promote cell death.

Drug usage cases: Xpovio is used together with bortezomib and/or dexamethasone to treat multiple myeloma in adults. It is used:

in combination with the medicines bortezomib and dexamethasone to treat adults with multiple myeloma who have received at least one prior treatment for their disease. in combination with dexamethasone to treat adults with multiple myeloma (MM) that has come back (relapsed) or that did not respond to previous treatment (refractory), and who have received at least 4 prior therapies, and whose disease did not respond to (refractory) to at least 2 proteasome inhibitor medicines, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody medicine. Xpovio is also used in adults to treat certain types of diffuse large B-cell lymphoma that has come back (relapsed) or that did not respond to previous treatment (refractory) and who have received at least 2 prior therapies.

Drug contra indications: To make sure Xpovio is safe for you, tell your doctor if you have:

cataracts; bleeding problems; or an active or recent infection. Xpovio is not approved for use by anyone younger than 18 years old.

Side effects: Get emergency medical help if you have signs of an allergic reaction to Xpovio: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Xpovio can cause serious or fatal side effects. Some side effects may not occur until you have been taking this medicine for several days or weeks. Call your doctor at once if you have:

blurred vision, tunnel vision, eye pain, or seeing halos around lights; severe ongoing nausea, vomiting, or diarrhea; loss of appetite that prevents you from eating and causes weight loss; confusion, dizziness, fainting, or changes in mental status; symptoms of sepsis – fever or chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill; signs of infection – fever, chills, flu symptoms, cough with mucus, mouth and throat ulcers, feeling short of breath, tingly or painful blistering rash on one side of your body; or low sodium level – headache, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Your treatments may be delayed or permanently discontinued if you have certain side effects.

Warnings: Xpovio affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms, cough, mouth ulcers, or trouble breathing, Xpovio can also cause low platelet counts in your blood. Tell your doctor right away if you have unusual bruising or bleeding.

Use during pregnancy or breastfeeding: You may need to have a negative pregnancy test before starting this treatment. Both men and women using this medicine should use effective birth control to prevent pregnancy. Selinexor can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Xpovio. This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selinexor can harm an unborn baby. Do not breastfeed while using this medicine, and for at least 1 week after your last dose.