Yusimry

Generic name: Adalimumab-aqvh

Drug class: TNF alfa inhibitors

Dosage forms: Subcutaneous injection

Root of administration: Subcutaneous

Dose: 40 mg/ 0.8 ml

Mechanism of action: Yusimry works as a TNF blocker that inhibits TNF, helping to reduce pain, inflammation, and skin symptoms.

Drug usage cases: Yusimry is a biosimilar of Humira; it is a TNF alfa inhibitor used to reduce pain, inflammation, and skin symptoms in chronic autoimmune conditions. Yusimry is used to treat rheumatoid arthritis (RA), psoriatic arthritis, plaque psoriasis, Crohn’s disease, ulcerative colitis, juvenile idiopathic arthritis, ankylosing spondylitis, and uveitis.

Drug contra indications: Before you start using Yusimry, tell your doctor if you have signs of infection – fever, chills, sweats, muscle aches, tiredness, cough, bloody mucus, skin sores, diarrhea, burning when you urinate, or feeling constantly tired. Yusimry should only be used in age groups for the specific conditions that Yusimry is FDA-approved to treat. Children using Yusimry should be current on all childhood immunizations before starting treatment. Tell your doctor if you have ever had:

tuberculosis (or if anyone in your household has tuberculosis); a chronic infection; cancer; hepatitis B (Yusimry can cause hepatitis B to come back or get worse); diabetes; heart failure; any numbness or tingling, or a nerve-muscle disorder such as multiple sclerosis or Guillain-Barre syndrome; an allergy to latex rubber; if you are scheduled to have major surgery; or if you have recently received or are scheduled to receive any vaccine. Tell your doctor where you live and if you have recently traveled or plan to travel. You may be exposed to infections that are common in certain areas of the world. Yusimry may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn’s disease or ulcerative colitis. However, anyone with an inflammatory autoimmune disorder may have a higher risk of lymphoma. Talk with your doctor about your own risk.

Side effects: Get emergency medical help if you have any of these signs of an allergic reaction to Yusimry: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor right away if you have any symptoms of lymphoma:

fever, swollen glands, night sweats, general feeling of illness; joint and muscle pain, skin rash, easy bruising or bleeding; pale skin, feeling light-headed or short of breath, cold hands and feet; pain in your upper stomach that may spread to your shoulder; or loss of appetite, feeling full after eating only a small amount, weight loss. Also call your doctor at once if you have:

new or worsening psoriasis (raised, silvery flaking of the skin); a sore or bump on your skin that does not heal; symptoms of sepsis – confusion, chills, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill; liver problems – body aches, tiredness, stomach pain, right-sided upper stomach pain, vomiting, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); lupus-like syndrome – joint pain or swelling, chest pain, shortness of breath, patchy skin color that worsens in sunlight; nerve problems – numbness, tingling, dizziness, vision problems, weakness in your arms or legs; or signs of tuberculosis – fever with ongoing cough, weight loss (fat or muscle). Older adults may be more likely to develop infections or cancer while using Yusimry.

Warnings: Yusimry affects your immune system. You may get infections more easily, even serious or fatal infections. Before or during treatment with Yusimry, tell your doctor if you have signs of infection such as fever, chills, aches, tiredness, cough, skin sores, diarrhea, or burning when you urinate. Your doctor should test you for tuberculosis (TB) before you start taking Yusimry and monitor you closely for signs and symptoms of TB during treatment. The chances of getting cancer may be increased for children and adults taking TNF-blockers.

Use during pregnancy or breastfeeding: It is not known whether Yusimry will harm an unborn baby. Tell your doctor if you are pregnant or planning a pregnancy. Make sure any doctor caring for your newborn baby knows if you used this medicine while you were pregnant, and especially before your baby receives any vaccines. It may be unsafe to breastfeed a baby while using Yusimry. Ask your doctor about any risks and the best way to feed your baby while on this medicine.